| 3. Round | 21/08/2021 | Canet Roussillon | - | Le Puy Foot 43 | 1:0 |  |
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| 4. Round | 28/08/2021 | Angers SCO II | - | Canet Roussillon | 2:0 | ||||
| 5. Round | 04/09/2021 | Canet Roussillon | - | Vendée Les Herbiers | 2:1 | ||||
| 6. Round | 11/09/2021 | Montpellier HSC (CFA) | - | Canet Roussillon | 0:0 | ||||
| 7. Round | 18/09/2021 | Canet Roussillon | - | FC Chamalières | 2:0 | ||||
| 8. Round | 25/09/2021 | Andrézieux-Bouthéon FC | - | Canet Roussillon | 1:1 | |
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| 11. Round | 06/11/2021 | Canet Roussillon | - | Bergerac Périgord FC | 0:3 | ||||
| 12. Round | 20/11/2021 | Canet Roussillon | - | Angoulême CFC | 0:0 | |
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| 14. Round | 11/12/2021 | Canet Roussillon | - | Moulins Yzeure Foot | 1:2 |
France