6. Round | 17/10/2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
7. Round | 24/10/2021 | OFI Heraklion | - | Lamia | 0:0 | ||||
8. Round | 31/10/2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
9. Round | 06/11/2021 | OFI Heraklion | - | Atromitos | 2:0 | ||||
10. Round | 20/11/2021 | Volos NFC | - | OFI Heraklion | 0:2 | ||||
11. Round | 28/11/2021 | OFI Heraklion | - | Ionikos Nikea | 2:1 | ||||
12. Round | 04/12/2021 | OFI Heraklion | - | Olympiakos Piraeus | 1:3 | ||||
14. Round | 16/12/2021 | OFI Heraklion | - | Aris Saloniki | 1:1 | ||||
15. Round | 20/12/2021 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
17. Round | 08/01/2022 | OFI Heraklion | - | PAS Giannina | 1:1 | ||||
13. Round | 12/01/2022 | Apollon Smyrnis | - | OFI Heraklion | 0:3 | ||||
18. Round | 15/01/2022 | PAOK Saloniki | - | OFI Heraklion | 3:0 | ||||
19. Round | 22/01/2022 | OFI Heraklion | - | Panetolikos | 2:4 | ||||
20. Round | 29/01/2022 | Lamia | - | OFI Heraklion | 2:1 | ||||
21. Round | 02/02/2022 | OFI Heraklion | - | Panathinaikos | 3:2 | ||||
23. Round | 13/02/2022 | OFI Heraklion | - | Volos NFC | 2:1 | ||||
22. Round | 16/02/2022 | Atromitos | - | OFI Heraklion | 2:2 |