Group F | 07/04/2022 | Antofagasta | - | Defensa y Justicia | 1:3 | ||||
Group F | 13/04/2022 | Defensa y Justicia | - | Atlético Goianiense | 0:1 | ||||
Group F | 28/04/2022 | Defensa y Justicia | - | LDU Quito | 1:2 | ||||
Group F | 25/05/2022 | Defensa y Justicia | - | Antofagasta | 0:2 |