1. Round | 14/08/2021 | FC Augsburg | - | 1899 Hoffenheim | 0:4 | ||||
2. Round | 22/08/2021 | 1899 Hoffenheim | - | 1. FC Union Berlin | 2:2 | ||||
3. Round | 27/08/2021 | Borussia Dortmund | - | 1899 Hoffenheim | 3:2 | ||||
4. Round | 11/09/2021 | 1899 Hoffenheim | - | 1. FSV Mainz 05 | 0:2 |