3. Round | 17/08/2021 | Colchester United | - | Mansfield Town | 1:1 | ||||
4. Round | 21/08/2021 | Oldham Athletic | - | Colchester United | 1:2 | ||||
5. Round | 27/08/2021 | Rochdale AFC | - | Colchester United | 1:1 | ||||
14. Round | 23/10/2021 | Port Vale FC | - | Colchester United | 3:0 | ||||
6. Round | 26/10/2021 | Colchester United | - | Sutton United | 1:3 | ||||
15. Round | 30/10/2021 | Colchester United | - | Scunthorpe United | 2:1 | ||||
27. Round | 15/01/2022 | Colchester United | - | Barrow AFC | 0:2 | ||||
24. Round | 18/01/2022 | Sutton United | - | Colchester United | 3:2 | ||||
30. Round | 05/02/2022 | Leyton Orient | - | Colchester United | 0:1 | ||||
36. Round | 12/03/2022 | Scunthorpe United | - | Colchester United | 1:3 | ||||
40. Round | 02/04/2022 | Harrogate Town | - | Colchester United | 1:2 | ||||
43. Round | 18/04/2022 | Colchester United | - | Bradford City | 3:0 |