| 1. Round | 24/07/2010 | Jaguares Chiapas | - | Club Necaxa | 1:1 |  |
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| 2. Round | 31/07/2010 | Club Necaxa | - | UANL Tigres | 0:2 | ||||
| 3. Round | 08/08/2010 | Atlas Guadalajara | - | Club Necaxa | 0:1 | |
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| 4. Round | 14/08/2010 | Club Necaxa | - | Gallos Blancos (old) | 1:1 |  |
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| 5. Round | 22/08/2010 | Monarcas Morelia | - | Club Necaxa | 1:0 | ||||
| 6. Round | 29/08/2010 | CF América | - | Club Necaxa | 1:1 | ||||
| 7. Round | 11/09/2010 | Club Necaxa | - | Deportivo Toluca | 1:1 | ||||
| 8. Round | 19/09/2010 | Santos Laguna | - | Club Necaxa | 2:1 | ||||
| 10. Round | 03/10/2010 | CF Monterrey | - | Club Necaxa | 2:1 | |
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| 11. Round | 09/10/2010 | Club Necaxa | - | Puebla FC | 1:0 | ||||
| 12. Round | 17/10/2010 | Deportivo Guadalajara | - | Club Necaxa | 1:0 | ||||
| 13. Round | 23/10/2010 | Club Necaxa | - | Club San Luis | 0:2 | ||||
| 14. Round | 28/10/2010 | Estudiantes Tecos | - | Club Necaxa | 0:2 | ||||
| 15. Round | 31/10/2010 | Club Necaxa | - | Atlante | 1:2 | |
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| 16. Round | 07/11/2010 | Pumas UNAM | - | Club Necaxa | 2:0 |
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