6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
8. Round | 03/04/2022 | Sol de América | - | General Caballero DJLM | 2:3 | ||||
9. Round | 09/04/2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
10. Round | 18/04/2022 | Resistencia SC | - | General Caballero DJLM | 2:1 | ||||
12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 |