1. Round | 25/07/2021 | RSC Anderlecht | - | Union Saint-Gilloise | 1:3 | ||||
2. Round | 31/07/2021 | KAS Eupen | - | RSC Anderlecht | 1:1 | ||||
4. Round | 15/08/2021 | Cercle Brugge | - | RSC Anderlecht | 1:2 | ||||
6. Round | 29/08/2021 | KRC Genk | - | RSC Anderlecht | 1:0 | ||||
7. Round | 12/09/2021 | RSC Anderlecht | - | KV Mechelen | 7:2 | ||||
8. Round | 19/09/2021 | Standard Liège | - | RSC Anderlecht | 0:1 | ||||
5. Round | 23/09/2021 | RSC Anderlecht | - | KAA Gent | 1:1 | ||||
9. Round | 26/09/2021 | KV Oostende | - | RSC Anderlecht | 2:2 | ||||
10. Round | 03/10/2021 | RSC Anderlecht | - | Club Brugge KV | 1:1 | ||||
11. Round | 17/10/2021 | Sint-Truidense VV | - | RSC Anderlecht | 2:2 | ||||
12. Round | 24/10/2021 | RSC Anderlecht | - | K Beerschot VA | 4:2 | ||||
13. Round | 31/10/2021 | RSC Anderlecht | - | Oud-Heverlee Leuven | 2:2 | ||||
14. Round | 07/11/2021 | Royal Antwerp FC | - | RSC Anderlecht | 2:0 | ||||
16. Round | 27/11/2021 | Sporting Charleroi | - | RSC Anderlecht | 1:3 | ||||
17. Round | 05/12/2021 | RSC Anderlecht | - | SV Zulte Waregem | 3:2 | ||||
19. Round | 14/12/2021 | RSC Anderlecht | - | Sint-Truidense VV | 2:0 |