 |
 |
|
|
| 28/02/2022 | 18:30 | RSC Anderlecht II | - | Club NXT | 1:0 | |
| 07/03/2022 | 18:30 | Sporting Charleroi II | - | Cercle Brugge II | 1:1 | |
| 28/03/2022 | 19:00 | Oud-Heverlee Leuven II | - | KV Mechelen II | 0:1 | |
| 15/04/2022 | 18:30 | SV Zulte Waregem II | - | KAA Gent II | 0:3 | |
| 18/04/2022 | 18:30 | Sint-Truidense VV II | - | Royal Antwerp FC II | 3:2 | |
| 28/04/2022 | 18:30 | Standard Liège II | - | KRC Genk II | 1:1 |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KRC Genk II | 17 | 14 | 3 | 0 | 49:15 | 34 | 45 |
| 2 |
|
RSC Anderlecht II | 17 | 13 | 2 | 2 | 40:11 | 29 | 41 |
| 3 |
|
KAA Gent II | 17 | 9 | 4 | 4 | 33:21 | 12 | 31 |
| 4 |
|
Club NXT | 17 | 9 | 3 | 5 | 38:12 | 26 | 30 |
| 5 |
|
Standard Liège II | 17 | 8 | 4 | 5 | 25:22 | 3 | 28 |
| 6 |
|
Sporting Charleroi II | 17 | 6 | 3 | 8 | 18:31 | -13 | 21 |
| 7 |
|
Sint-Truidense VV II | 17 | 5 | 4 | 8 | 19:29 | -10 | 19 |
| 8 |
|
Oud-Heverlee Leuven II | 17 | 5 | 2 | 10 | 20:29 | -9 | 17 |
| 9 |
|
SV Zulte Waregem II | 17 | 4 | 3 | 10 | 24:40 | -16 | 15 |
| 10 |
|
Cercle Brugge II | 17 | 3 | 5 | 9 | 20:30 | -10 | 14 |
| 11 |
|
KV Mechelen II | 17 | 3 | 4 | 10 | 12:40 | -28 | 13 |
| 12 |
|
Royal Antwerp FC II | 17 | 3 | 3 | 11 | 20:38 | -18 | 12 |
| Relegation |
