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| 1st(1st leg) | Toronto FC | - | Motagua | 1:0 | ||
| 2nd (2nd leg) | Motagua | - | Toronto FC | 2:2 | ||
| 1st(1st leg): 28/07/2010 01:00 | 2nd (2nd leg): 04/08/2010 01:00 | Winner: Toronto FC | ||||
| 1st(1st leg) | San Juan Jabloteh | - | Santos Laguna | 0:1 | ||
| 2nd (2nd leg) | Santos Laguna | - | San Juan Jabloteh | 5:0 | ||
| 1st(1st leg): 28/07/2010 01:00 | 2nd (2nd leg): 05/08/2010 03:00 | Winner: Santos Laguna | ||||
| 1st(1st leg) | Los Angeles Galaxy | - | Puerto Rico Islanders | 1:4 | ||
| 2nd (2nd leg) | Puerto Rico Islanders | - | Los Angeles Galaxy | 1:2 | ||
| 1st(1st leg): 28/07/2010 03:00 | 2nd (2nd leg): 05/08/2010 01:00 | Winner: Puerto Rico Islanders | ||||
| 1st(1st leg) | San Francisco FC | - | Cruz Azul | 2:3 | ||
| 2nd (2nd leg) | Cruz Azul | - | San Francisco FC | 6:0 | ||
| 1st(1st leg): 28/07/2010 03:35 | 2nd (2nd leg): 04/08/2010 01:00 | Winner: Cruz Azul | ||||
| 1st(1st leg) | Tauro FC | - | Marathón | 0:3 | ||
| 2nd (2nd leg) | Marathón | - | Tauro FC | 1:2 | ||
| 1st(1st leg): 29/07/2010 01:00 | 2nd (2nd leg): 05/08/2010 03:00 | Winner: Marathón | ||||
| 1st(1st leg) | Brujas de Escazú | - | Joe Public FC | 2:2 | ||
| 2nd (2nd leg) | Joe Public FC | - | Brujas de Escazú | 4:2 | ||
| 1st(1st leg): 29/07/2010 01:00 | 2nd (2nd leg): 06/08/2010 01:00 | Winner: Joe Public FC | ||||
| 1st(1st leg) | Seattle Sounders | - | Isidro Metapán | 1:0 | ||
| 2nd (2nd leg) | Isidro Metapán | - | Seattle Sounders | 1:1 | ||
| 1st(1st leg): 29/07/2010 01:00 | 2nd (2nd leg): 04/08/2010 03:00 | Winner: Seattle Sounders | ||||
| 1st(1st leg) | FAS | - | Xelaju MC | 1:1 | ||
| 2nd (2nd leg) | Xelaju MC | - | FAS | 0:2 | ||
| 1st(1st leg): 30/07/2010 03:00 | 2nd (2nd leg): 06/08/2010 03:00 | Winner: FAS | ||||
