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| 1st(1st leg) | Colo-Colo | - | Club Olimpia | 2:5 (1:2) | ||
| 2nd (2nd leg) | Club Olimpia | - | Colo-Colo | 1:2 (1:1) | ||
| 1st(1st leg): 09/04/1961 | 2nd (2nd leg): 16/04/1961 | Winner: Club Olimpia | ||||
| 1st(1st leg) | Peñarol | - | Universitario de Deportes | 5:0 (2:0) | ||
| 2nd (2nd leg) | Universitario de Deportes | - | Peñarol | 2:0 (0:0) | ||
| 1st(1st leg): 19/04/1961 | 2nd (2nd leg): 14/05/1961 | Winner: Peñarol | ||||
| 1st(1st leg) | Jorge Wilstermann | - | Santa Fe | 3:2 (2:1) | ||
| 2nd (2nd leg) | Santa Fe | - | Jorge Wilstermann | 1:0 (1:0) | ||
| 1st(1st leg): 30/04/1961 | 2nd (2nd leg): 07/05/1961 | Winner: Santa Fe | ||||
| 1st(1st leg) | Independiente | - | Palmeiras | 0:2 (0:1) | ||
| 2nd (2nd leg) | Palmeiras | - | Independiente | 1:0 (1:0) | ||
| 1st(1st leg): 04/05/1961 | 2nd (2nd leg): 11/05/1961 | Winner: Palmeiras | ||||
