 |
 |
|
|
| 1st(1st leg) | Montevideo Wanderers | - | Bolívar | 1:0 (0:0) | ||
| 2nd (2nd leg) | Bolívar | - | Montevideo Wanderers | 5:0 (2:0) | ||
| 1st(1st leg): 09/03/2021 22:15 | 2nd (2nd leg): 16/03/2021 22:15 | Winner: Bolívar | ||||
| 1st(1st leg) | Santos FC | - | Deportivo Lara | 2:1 (0:0) | ||
| 2nd (2nd leg) | Deportivo Lara | - | Santos FC | 1:1 (0:1) | ||
| 1st(1st leg): 09/03/2021 22:15 | 2nd (2nd leg): 16/03/2021 22:15 | Winner: Santos FC | ||||
| 1st(1st leg) | Unión Española | - | Independiente del Valle | 1:0 (0:0) | ||
| 2nd (2nd leg) | Independiente del Valle | - | Unión Española | 6:2 (4:0) | ||
| 1st(1st leg): 10/03/2021 00:30 | 2nd (2nd leg): 17/03/2021 00:30 | Winner: Independiente del Valle | ||||
| 1st(1st leg) | Universidad Catolica | - | Libertad | 0:1 (0:1) | ||
| 2nd (2nd leg) | Libertad | - | Universidad Catolica | 2:2 (1:0) | ||
| 1st(1st leg): 10/03/2021 22:15 | 2nd (2nd leg): 17/03/2021 22:15 | Winner: Libertad | ||||
| 1st(1st leg) | Grêmio Porto Alegre | - | Ayacucho FC | 6:1 (4:0) | ||
| 2nd (2nd leg) | Ayacucho FC | - | Grêmio Porto Alegre | 1:2 (1:1) | ||
| 1st(1st leg): 11/03/2021 00:30 | 2nd (2nd leg): 17/03/2021 00:30 | Winner: Grêmio Porto Alegre | ||||
| 1st(1st leg) | Universidad de Chile | - | San Lorenzo | 1:1 (0:0) | ||
| 2nd (2nd leg) | San Lorenzo | - | Universidad de Chile | 2:0 (1:0) | ||
| 1st(1st leg): 11/03/2021 00:30 | 2nd (2nd leg): 18/03/2021 00:30 | Winner: San Lorenzo | ||||
| 1st(1st leg) | Caracas FC | - | Atlético Junior | 1:2 (1:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Caracas FC | 3:1 (1:0) | ||
| 1st(1st leg): 11/03/2021 00:30 | 2nd (2nd leg): 18/03/2021 00:30 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Guaraní | - | Atlético Nacional | 0:2 (0:1) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Guaraní | 3:0 (2:0) | ||
| 1st(1st leg): 12/03/2021 00:30 | 2nd (2nd leg): 19/03/2021 00:30 | Winner: Atlético Nacional | ||||
