1st(1st leg) Congo DR - Cameroon 0:2
2nd (2nd leg) Cameroon - Congo DR 3:0
1st(1st leg): 21/05/2010 15:30 2nd (2nd leg): 05/06/2010 15:30 Winner: Cameroon
1st(1st leg) Algeria - Tunisia 1:1
2nd (2nd leg) Tunisia - Algeria 0:1
1st(1st leg): 22/05/2010 16:00 2nd (2nd leg): 05/06/2010 17:00 Winner: Algeria
1st(1st leg) Senegal - Ghana 1:0
2nd (2nd leg) Ghana - Senegal 3:0
1st(1st leg): 22/05/2010 18:00 2nd (2nd leg): 06/06/2010 12:30 Winner: Ghana
1st(1st leg) Tanzania - Eritrea 8:0
2nd (2nd leg) Eritrea - Tanzania 3:3
1st(1st leg): 23/05/2010 14:00 2nd (2nd leg): 05/06/2010 12:00 Winner: Tanzania
1st(1st leg) Namibia - Equatorial Guinea 1:5
1st(1st leg): 23/05/2010 16:00 2nd (2nd leg):
1st(1st leg) Guinea - Mali 0:2
2nd (2nd leg) Mali - Guinea 1:2
1st(1st leg): 23/05/2010 16:00 2nd (2nd leg): 05/06/2010 12:00 Winner: Mali
1st(1st leg) Ivory Coast - Nigeria 1:2
2nd (2nd leg) Nigeria - Ivory Coast 3:1
1st(1st leg): 23/05/2010 16:30 2nd (2nd leg): 05/06/2010 16:00 Winner: Nigeria

# Nambia zog nach dem Hinspiel der 1. Runde zurück und trat zum Rückspiel nicht mehr an.