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| 23/03/2022 | 18:00 | ADO '20 | - | Quick Den Haag | 0:1 (0:0) | |
| 18:00 | VV Dongen | - | VV Hoogland | 2:0 (2:0) | ||
| 18:00 | HVV Hollandia | - | OSS '20 | 3:1 (1:1) | ||
| 18:00 | JOS Watergraafsmeer | - | HSC'21 | 1:0 (0:0) | ||
| 18:00 | Unitas Gorinchem | - | Blauw Geel '38 | 0:0 (0:0) | ||
| 18:00 | VV Gemert | - | RKVV DEM | 3:3 (2:0) | ||
| 18:30 | VV UNA | - | USV Hercules | 1:5 (0:3) | ||
| 19:15 | EVV | - | RKVV Westlandia | 2:0 (0:0) | ||
| 30/03/2022 | 18:30 | OFC Oostzaan | - | RKSV Groene Ster | 2:2 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VV Gemert | 21 | 12 | 8 | 1 | 48:30 | 18 | 44 |
| 2 |
|
OFC Oostzaan | 21 | 14 | 2 | 5 | 46:31 | 15 | 44 |
| 3 |
|
RKSV Groene Ster | 21 | 10 | 7 | 4 | 32:26 | 6 | 37 |
| 4 |
|
VV Dongen | 21 | 9 | 8 | 4 | 34:24 | 10 | 35 |
| 5 |
|
ADO '20 | 21 | 11 | 1 | 9 | 36:29 | 7 | 34 |
| 6 |
|
VV UNA | 21 | 10 | 4 | 7 | 37:34 | 3 | 34 |
| 7 |
|
USV Hercules | 21 | 10 | 3 | 8 | 40:30 | 10 | 33 |
| 8 |
|
OSS '20 | 21 | 10 | 3 | 8 | 40:31 | 9 | 32 |
| 9 |
|
Unitas Gorinchem | 21 | 9 | 3 | 9 | 27:38 | -11 | 30 |
| 10 |
|
Quick Den Haag | 21 | 9 | 2 | 10 | 25:26 | -1 | 29 |
| 11 |
|
JOS Watergraafsmeer | 21 | 9 | 3 | 9 | 39:39 | 0 | 28 |
| 12 |
|
HSC'21 | 21 | 8 | 2 | 11 | 37:30 | 7 | 26 |
| 13 |
|
Blauw Geel '38 | 21 | 7 | 3 | 11 | 35:34 | 1 | 24 |
| 14 |
|
EVV | 21 | 4 | 9 | 8 | 18:29 | -11 | 21 |
| 15 |
|
HVV Hollandia | 21 | 6 | 3 | 12 | 20:33 | -13 | 21 |
| 16 |
|
VV Hoogland | 21 | 5 | 4 | 12 | 22:43 | -21 | 19 |
| 17 |
|
RKVV Westlandia | 21 | 4 | 6 | 11 | 21:29 | -8 | 18 |
| 18 |
|
RKVV DEM | 21 | 4 | 5 | 12 | 17:38 | -21 | 17 |
| Promotion | |
| Playoffs | |
| Relegation |
