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| 02/04/2022 | 15:30 | FC Groningen | - | AFC Ajax | 1:3 (1:2) | |
| 17:45 | FC Twente | - | PSV Eindhoven | 3:3 (3:1) | ||
| 19:00 | AZ Alkmaar | - | Vitesse | 3:1 (1:0) | ||
| 19:00 | RKC Waalwijk | - | FC Utrecht | 1:1 (0:1) | ||
| 20:00 | Feyenoord | - | Willem II | 2:0 (0:0) | ||
| 03/04/2022 | 11:15 | PEC Zwolle | - | Go Ahead Eagles | 0:1 (0:0) | |
| 13:30 | Fortuna Sittard | - | Heracles Almelo | 0:2 (0:0) | ||
| 13:30 | Sparta Rotterdam | - | sc Heerenveen | 1:1 (0:0) | ||
| 15:45 | SC Cambuur | - | NEC Nijmegen | 1:2 (1:1) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AFC Ajax | 28 | 22 | 3 | 3 | 83:14 | 69 | 69 |
| 2 |
|
PSV Eindhoven | 28 | 21 | 2 | 5 | 71:34 | 37 | 65 |
| 3 |
|
Feyenoord | 28 | 18 | 4 | 6 | 63:27 | 36 | 58 |
| 4 |
|
AZ Alkmaar | 28 | 17 | 4 | 7 | 55:33 | 22 | 55 |
| 5 |
|
FC Twente | 28 | 16 | 7 | 5 | 44:33 | 11 | 55 |
| 6 |
|
FC Utrecht | 28 | 11 | 8 | 9 | 45:37 | 8 | 41 |
| 7 |
|
Vitesse | 28 | 12 | 5 | 11 | 34:44 | -10 | 41 |
| 8 |
|
FC Groningen | 28 | 9 | 9 | 10 | 36:40 | -4 | 36 |
| 9 |
|
NEC Nijmegen | 28 | 9 | 8 | 11 | 35:44 | -9 | 35 |
| 10 |
|
Go Ahead Eagles | 28 | 9 | 6 | 13 | 31:43 | -12 | 33 |
| 11 |
|
SC Cambuur | 28 | 10 | 3 | 15 | 44:60 | -16 | 33 |
| 12 |
|
sc Heerenveen | 28 | 8 | 7 | 13 | 25:37 | -12 | 31 |
| 13 |
|
Heracles Almelo | 28 | 8 | 6 | 14 | 29:37 | -8 | 30 |
| 14 |
|
RKC Waalwijk | 28 | 6 | 10 | 12 | 31:44 | -13 | 28 |
| 15 |
|
Sparta Rotterdam | 28 | 5 | 10 | 13 | 21:41 | -20 | 25 |
| 16 |
|
Fortuna Sittard | 28 | 7 | 4 | 17 | 29:60 | -31 | 25 |
| 17 |
|
Willem II | 28 | 6 | 5 | 17 | 23:48 | -25 | 23 |
| 18 |
|
PEC Zwolle | 28 | 5 | 5 | 18 | 20:43 | -23 | 20 |
| Champions League | |
| Champions League Quali. | |
| Europa League Quali. | |
| Playoffs | |
| Playoffs | |
| Relegation |
