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| 14/08/2010 | 10:45 | FK Tom Tomsk | - | Krylia Sovetov | 1:1 (0:0) | |
| 13:00 | Zenit St. Petersburg | - | Dinamo Moskva | 1:1 (1:1) | ||
| 16:30 | FK Saturn | - | FK Rostov | 0:2 (0:1) | ||
| 17:45 | Spartak Nalchik | - | Sibir Novosibirsk | 4:2 (2:1) | ||
| 15/08/2010 | 14:45 | FK Amkar Perm | - | Spartak Vladikavkaz | 1:0 (0:0) | |
| 17:30 | CSKA Moskva | - | Anzhi Makhachkala | 4:0 (4:0) | ||
| 17:45 | Terek Grozny | - | Rubin Kazan | 1:1 (1:0) | ||
| 18:20 | Lokomotiv Moskva | - | Spartak Moskva | 2:3 (1:2) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Zenit St. Petersburg | 17 | 12 | 4 | 1 | 26:8 | 18 | 40 |
| 2 |
|
CSKA Moskva | 17 | 10 | 4 | 3 | 28:13 | 15 | 34 |
| 3 |
|
Rubin Kazan | 17 | 9 | 6 | 2 | 18:7 | 11 | 33 |
| 4 |
|
Spartak Nalchik | 17 | 9 | 4 | 4 | 25:18 | 7 | 31 |
| 5 |
|
FK Rostov | 17 | 9 | 1 | 7 | 19:22 | -3 | 28 |
| 6 |
|
Spartak Moskva | 17 | 7 | 5 | 5 | 24:20 | 4 | 26 |
| 7 |
|
Lokomotiv Moskva | 17 | 6 | 5 | 6 | 22:18 | 4 | 23 |
| 8 |
|
FK Tom Tomsk | 17 | 6 | 4 | 7 | 22:25 | -3 | 22 |
| 9 |
|
Terek Grozny | 17 | 5 | 6 | 6 | 16:15 | 1 | 21 |
| 10 |
|
Dinamo Moskva | 17 | 4 | 9 | 4 | 17:17 | 0 | 21 |
| 11 |
|
FK Saturn | 17 | 5 | 5 | 7 | 12:15 | -3 | 20 |
| 12 |
|
Anzhi Makhachkala | 17 | 5 | 4 | 8 | 17:21 | -4 | 19 |
| 13 |
|
Spartak Vladikavkaz | 17 | 5 | 3 | 9 | 16:25 | -9 | 18 |
| 14 |
|
FK Amkar Perm | 17 | 4 | 3 | 10 | 11:19 | -8 | 15 |
| 15 |
|
Krylia Sovetov | 17 | 2 | 6 | 9 | 10:24 | -14 | 12 |
| 16 |
|
Sibir Novosibirsk | 17 | 2 | 3 | 12 | 23:39 | -16 | 9 |
| Champions League | |
| Champions League Quali. | |
| Europa League | |
| Relegation |
