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| 23/10/2018 | 13:30 | ŠTK 1914 Šamorín | - | FK Poprad | 7:8 (0:0, 1:1) pso | |
| 15:00 | FC Nitra | - | Tatran Liptovský Mikuláš | 3:1 (1:2, 2:2) pso | ||
| 15:30 | MFK Zemplín Michalovce | - | SK Odeva Lipany | 4:2 (2:1) | ||
| 18:00 | FK Senica | - | FC DAC 1904 | 5:1 (1:1) | ||
| 24/10/2018 | 13:30 | FC Košice | - | Zlaté Moravce | 3:1 (2:1) | |
| 17:00 | MFK Skalica | - | AS Trenčín | 2:1 (0:1) | ||
| 06/11/2018 | 16:00 | MŠK Žilina | - | ŠKF Sereď | 3:1 (2:1) | |
| 16/11/2018 | 14:00 | Železiarne Podbrezová | - | Spartak Trnava | 0:2 (0:2) |
