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| 06/08/2021 | 19:00 | Ruthin Town | - | Caernarfon Town | 0:3 (0:2) | |
| 19:00 | Undy Athletic | - | Swansea University | 5:3 (0:1, 1:1) pso | ||
| 19:45 | Airbus UK | - | Buckley Town | 3:2 (2:0) | ||
| 19:45 | Conwy Borough FC | - | Holywell Town | 1:3 (1:3) | ||
| 19:45 | Llandudno FC | - | Connah's Quay Nomads | 0:2 (0:1) | ||
| 19:45 | Prestatyn Town | - | Cefn Druids | 3:0 (3:0) | ||
| 19:45 | Ammanford AFC | - | Cardiff Metropolitan | 0:4 (0:2) | ||
| 20:00 | Aberystwyth Town | - | Penybont FC | 5:4 (0:1, 1:1) pso | ||
| 07/08/2021 | 14:30 | Flint Town United | - | Bala Town | 1:3 (0:1, 1:1) pso | |
| 14:30 | Gresford Athletic | - | Bangor City | 0:1 (0:1) | ||
| 14:30 | Penrhyncoch FC | - | The New Saints | 2:1 (1:0) | ||
| 14:30 | Barry Town United | - | Llanelli Town | 5:0 (3:0) | ||
| 14:30 | Cambrian & Clydach | - | Newtown AFC | 2:4 (1:2) | ||
| 14:30 | Cwmbran Celtic | - | Pontypridd Town | 1:2 (1:0) | ||
| 14:30 | Haverfordwest County | - | Goytre United | 3:0 (0:0) | ||
| 14:30 | Trefelin BGC | - | Risca United | 2:0 (1:0) |
