Championship   M. W D L goals
  at home 6 1 5 0 6 : 5
  Away 6 2 2 2 7 : 7
  12 3 7 2 13 : 12
League One   M. W D L goals
  at home 1 0 0 1 2 : 3
  Away 1 1 0 0 2 : 1
  2 1 0 1 4 : 4
League Two   M. W D L goals
  at home 6 3 2 1 8 : 4
  Away 6 3 2 1 10 : 7
  12 6 4 2 18 : 11
EFL Trophy   M. W D L goals
  Away 1 0 0 1 0 : 5
  1 0 0 1 0 : 5
overall   M. W D L goals
  at home 13 4 7 2 16 : 12
  Away 14 6 4 4 19 : 20
  Neutral Place 0 0 0 0 0 : 0
  27 10 11 6 35 : 32
Championship
1975/1976 9. Round Leyton Orient - Oxford United 2:1
1975/1976 3. Round Oxford United - Leyton Orient 2:1
1974/1975 8. Round Leyton Orient - Oxford United 1:1
1974/1975 2. Round Oxford United - Leyton Orient 1:2
1973/1974 8. Round Leyton Orient - Oxford United 1:1
1973/1974 3. Round Oxford United - Leyton Orient 1:1
1972/1973 7. Round Oxford United - Leyton Orient 2:1
1972/1973 1. Round Leyton Orient - Oxford United 1:1
1971/1972 3. Round Leyton Orient - Oxford United 1:1
1971/1972 1. Round Oxford United - Leyton Orient 1:1
1970/1971 9. Round Leyton Orient - Oxford United 0:0
1970/1971 8. Round Oxford United - Leyton Orient 0:1
League One
2023/2024 35. Round Oxford United - Leyton Orient 1:2 (1:0)
2023/2024 17. Round Leyton Orient - Oxford United 2:3 (0:2)
League Two
2015/2016 36. Round Oxford United - Leyton Orient 0:1 (0:0)
2015/2016 13. Round Leyton Orient - Oxford United 2:2 (0:2)
2005/2006 46. Round Oxford United - Leyton Orient 2:3 (1:1)
2005/2006 16. Round Leyton Orient - Oxford United 1:0 (1:0)
2004/2005 40. Round Oxford United - Leyton Orient 2:2
2004/2005 4. Round Leyton Orient - Oxford United 0:0
2003/2004 30. Round Leyton Orient - Oxford United 1:0
2003/2004 23. Round Oxford United - Leyton Orient 2:1
2002/2003 35. Round Oxford United - Leyton Orient 0:2
2002/2003 9. Round Leyton Orient - Oxford United 1:2
2001/2002 44. Round Oxford United - Leyton Orient 1:1
2001/2002 19. Round Leyton Orient - Oxford United 3:0
EFL Trophy
2022/2023 Group G South Oxford United - Leyton Orient 5:0 (2:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking