FA Cup   M. W D L goals
  at home 3 2 0 1 8 : 2
  Away 2 0 2 0 3 : 3
  5 2 2 1 11 : 5
League One   M. W D L goals
  at home 8 5 0 3 12 : 8
  Away 8 2 2 4 9 : 12
  16 7 2 7 21 : 20
League Two   M. W D L goals
  at home 3 1 0 2 3 : 4
  Away 3 1 0 2 1 : 2
  6 2 0 4 4 : 6
National League   M. W D L goals
  at home 1 0 1 0 1 : 1
  Away 1 0 0 1 1 : 2
  2 0 1 1 2 : 3
overall   M. W D L goals
  at home 15 8 1 6 24 : 15
  Away 14 3 4 7 14 : 19
  Neutral Place 0 0 0 0 0 : 0
  29 11 5 13 38 : 34
FA Cup
2021/2022 2. Round Leyton Orient - Tranmere Rovers 4:0 (2:0)
2009/2010 1. Round Leyton Orient - Tranmere Rovers 0:1 (0:0)
2009/2010 1. Round Tranmere Rovers - Leyton Orient 1:1 (0:1)
1953/1954 3. Round Leyton Orient - Tranmere Rovers 4:1
1953/1954 3. Round Tranmere Rovers - Leyton Orient 2:2
League One
2013/2014 45. Round Leyton Orient - Tranmere Rovers 2:0 (1:0)
2013/2014 12. Round Tranmere Rovers - Leyton Orient 0:4 (0:1)
2012/2013 32. Round Leyton Orient - Tranmere Rovers 2:1 (1:0)
2012/2013 1. Round Tranmere Rovers - Leyton Orient 3:1 (1:0)
2011/2012 36. Round Tranmere Rovers - Leyton Orient 2:0 (2:0)
2011/2012 2. Round Leyton Orient - Tranmere Rovers 0:1 (0:0)
2010/2011 45. Round Leyton Orient - Tranmere Rovers 0:3 (0:2)
2010/2011 20. Round Tranmere Rovers - Leyton Orient 1:2 (0:2)
2009/2010 32. Round Tranmere Rovers - Leyton Orient 2:1 (2:0)
2009/2010 17. Round Leyton Orient - Tranmere Rovers 2:1 (1:1)
2008/2009 31. Round Tranmere Rovers - Leyton Orient 0:0 (0:0)
2008/2009 11. Round Leyton Orient - Tranmere Rovers 0:1 (0:1)
2007/2008 31. Round Tranmere Rovers - Leyton Orient 1:1 (1:0)
2007/2008 25. Round Leyton Orient - Tranmere Rovers 3:0 (1:0)
2006/2007 35. Round Leyton Orient - Tranmere Rovers 3:1 (3:1)
2006/2007 6. Round Tranmere Rovers - Leyton Orient 3:0 (2:0)
League Two
2022/2023 29. Round Tranmere Rovers - Leyton Orient 1:0 (0:0)
2022/2023 7. Round Leyton Orient - Tranmere Rovers 2:0 (1:0)
2021/2022 46. Round Leyton Orient - Tranmere Rovers 0:1 (0:1)
2021/2022 22. Round Tranmere Rovers - Leyton Orient 1:0 (0:0)
2020/2021 32. Round Leyton Orient - Tranmere Rovers 1:3 (0:1)
2020/2021 7. Round Tranmere Rovers - Leyton Orient 0:1 (0:0)
National League
2017/2018 33. Round Leyton Orient - Tranmere Rovers 1:1 (0:1)
2017/2018 14. Round Tranmere Rovers - Leyton Orient 2:1 (1:1)

For games that were decided on penalties the score after 120 minutes will be included in the ranking