Premier League   M. W D L goals
  at home 10 5 4 1 30 : 15
  Away 10 2 2 6 13 : 21
  20 7 6 7 43 : 36
Championship   M. W D L goals
  at home 17 6 3 8 28 : 32
  Away 17 6 3 8 30 : 29
  34 12 6 16 58 : 61
FA Cup   M. W D L goals
  at home 2 1 1 0 3 : 2
  Away 3 0 0 3 0 : 10
  5 1 1 3 3 : 12
League Cup   M. W D L goals
  at home 1 0 1 0 1 : 1
  Away 1 1 0 0 2 : 1
  2 1 1 0 3 : 2
overall   M. W D L goals
  at home 30 12 9 9 62 : 50
  Away 31 9 5 17 45 : 61
  Neutral Place 0 0 0 0 0 : 0
  61 21 14 26 107 : 111
Premier League
1991/1992 35. Round Southampton FC - Luton Town 2:1 (0:1)
1991/1992 6. Round Luton Town - Southampton FC 2:1 (2:1)
1990/1991 22. Round Luton Town - Southampton FC 3:4 (2:2)
1990/1991 3. Round Southampton FC - Luton Town 1:2 (1:2)
1989/1990 27. Round Luton Town - Southampton FC 1:1 (1:1)
1989/1990 15. Round Southampton FC - Luton Town 6:3 (2:1)
1988/1989 20. Round Luton Town - Southampton FC 6:1 (2:0)
1988/1989 3. Round Southampton FC - Luton Town 2:1 (1:0)
1987/1988 42. Round Southampton FC - Luton Town 1:1 (0:1)
1987/1988 21. Round Luton Town - Southampton FC 2:2 (1:1)
1986/1987 25. Round Southampton FC - Luton Town 3:0 (2:0)
1986/1987 2. Round Luton Town - Southampton FC 2:1 (1:0)
1985/1986 29. Round Southampton FC - Luton Town 1:2 (0:1)
1985/1986 13. Round Luton Town - Southampton FC 7:0 (3:0)
1984/1985 27. Round Southampton FC - Luton Town 1:0 (0:0)
1984/1985 5. Round Luton Town - Southampton FC 1:1 (0:0)
1983/1984 29. Round Southampton FC - Luton Town 2:1 (2:0)
1983/1984 10. Round Luton Town - Southampton FC 3:1 (2:0)
1982/1983 39. Round Southampton FC - Luton Town 2:2 (2:2)
1982/1983 16. Round Luton Town - Southampton FC 3:3 (0:2)
Championship
2006/2007 41. Round Luton Town - Southampton FC 0:2 (0:2)
2006/2007 19. Round Southampton FC - Luton Town 2:1 (2:0)
2005/2006 23. Round Southampton FC - Luton Town 1:0 (1:0)
2005/2006 2. Round Luton Town - Southampton FC 3:2 (1:2)
1977/1978 9. Round Luton Town - Southampton FC 1:2
1977/1978 5. Round Southampton FC - Luton Town 0:1
1976/1977 9. Round Southampton FC - Luton Town 1:0
1976/1977 3. Round Luton Town - Southampton FC 1:4
1975/1976 8. Round Luton Town - Southampton FC 1:0
1975/1976 4. Round Southampton FC - Luton Town 3:1
1962/1963 1. Round Luton Town - Southampton FC 3:2
1962/1963 1. Round Southampton FC - Luton Town 2:2
1961/1962 7. Round Southampton FC - Luton Town 3:0
1961/1962 2. Round Luton Town - Southampton FC 1:4
1960/1961 9. Round Southampton FC - Luton Town 3:2
1960/1961 5. Round Luton Town - Southampton FC 4:1
1952/1953 7. Round Luton Town - Southampton FC 1:2
1952/1953 3. Round Southampton FC - Luton Town 1:3
1951/1952 8. Round Luton Town - Southampton FC 2:1
1951/1952 4. Round Southampton FC - Luton Town 2:3
1950/1951 5. Round Southampton FC - Luton Town 1:1
1950/1951 2. Round Luton Town - Southampton FC 0:1
1949/1950 5. Round Southampton FC - Luton Town 2:1
1949/1950 5. Round Luton Town - Southampton FC 1:1
1948/1949 6. Round Southampton FC - Luton Town 1:1
1948/1949 2. Round Luton Town - Southampton FC 1:1
1947/1948 9. Round Luton Town - Southampton FC 0:2
1947/1948 4. Round Southampton FC - Luton Town 3:1
1946/1947 7. Round Southampton FC - Luton Town 1:3
1946/1947 3. Round Luton Town - Southampton FC 2:2
1938/1939 9. Round Southampton FC - Luton Town 0:4
1938/1939 9. Round Luton Town - Southampton FC 6:2
1937/1938 8. Round Luton Town - Southampton FC 1:3
1937/1938 3. Round Southampton FC - Luton Town 3:6
FA Cup
2009/2010 3. Round Southampton FC - Luton Town 1:0 (1:0)
1994/1995 4. Round Southampton FC - Luton Town 6:0 (4:0)
1994/1995 4. Round Luton Town - Southampton FC 1:1 (0:0)
1987/1988 4. Round Luton Town - Southampton FC 2:1
1914/1915 1. Round Southampton FC - Luton Town 3:0
League Cup
1988/1989 Quarter-finals Southampton FC - Luton Town 1:2 aet
1988/1989 Quarter-finals Luton Town - Southampton FC 1:1

For games that were decided on penalties the score after 120 minutes will be included in the ranking