1. Round | 06/02/2022 | Boston River | - | Plaza Colonia | 0:0 | ||||
2. Round | 13/02/2022 | Boston River | - | Cerrito | 0:1 | ||||
3. Round | 19/02/2022 | River Plate | - | Boston River | 1:2 | ||||
4. Round | 25/02/2022 | Boston River | - | Cerro Largo | 3:0 | ||||
5. Round | 12/03/2022 | Fénix | - | Boston River | 0:2 | ||||
6. Round | 21/03/2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
12. Round | 16/05/2022 | Boston River | - | Liverpool | 2:3 | ||||
13. Round | 21/05/2022 | Peñarol | - | Boston River | 1:0 | ||||
14. Round | 28/05/2022 | Boston River | - | Montevideo City Torque | 3:1 | ||||
15. Round | 06/06/2022 | Montevideo Wanderers | - | Boston River | 1:2 |