1. Round | 10/01/2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
3. Round | 22/01/2022 | Mazatlán FC | - | Deportivo Toluca | 1:2 | ||||
4. Round | 07/02/2022 | UANL Tigres | - | Mazatlán FC | 4:3 | ||||
5. Round | 12/02/2022 | Mazatlán FC | - | Club Tijuana | 2:0 | ||||
2. Round | 17/02/2022 | Mazatlán FC | - | CF América | 2:1 | ||||
6. Round | 19/02/2022 | Gallos Blancos | - | Mazatlán FC | 2:0 | ||||
7. Round | 25/02/2022 | CF Pachuca | - | Mazatlán FC | 3:1 | ||||
8. Round | 02/03/2022 | Mazatlán FC | - | Club Necaxa | 0:0 |