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| 1st(1st leg) | Arsenal de Sarandí | - | Mineros de Guayana | 2:0 (1:0) | ||
| 2nd (2nd leg) | Mineros de Guayana | - | Arsenal de Sarandí | 2:1 (1:0) | ||
| 1st(1st leg): 29/01/2008 | 2nd (2nd leg): 05/02/2008 | Winner: Arsenal de Sarandí | ||||
| 1st(1st leg) | Cruzeiro | - | Cerro Porteño | 3:1 (1:0) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Cruzeiro | abor. | ||
| 1st(1st leg): 30/01/2008 | 2nd (2nd leg): 07/02/2008 | Winner: Cruzeiro | ||||
| 1st(1st leg) | Atlas Guadalajara | - | La Paz FC | 2:0 (1:0) | ||
| 2nd (2nd leg) | La Paz FC | - | Atlas Guadalajara | 1:0 (0:0) | ||
| 1st(1st leg): 30/01/2008 | 2nd (2nd leg): 06/02/2008 | Winner: Atlas Guadalajara | ||||
| 1st(1st leg) | Olmedo | - | Lanús | 1:0 (0:0) | ||
| 2nd (2nd leg) | Lanús | - | Olmedo | 3:0 (0:0) | ||
| 1st(1st leg): 31/01/2008 | 2nd (2nd leg): 05/02/2008 | Winner: Lanús | ||||
| 1st(1st leg) | Cienciano | - | Montevideo Wanderers | 1:0 (1:0) | ||
| 2nd (2nd leg) | Montevideo Wanderers | - | Cienciano | 0:0 (0:0) | ||
| 1st(1st leg): 31/01/2008 | 2nd (2nd leg): 07/02/2008 | Winner: Cienciano | ||||
| 1st(1st leg) | Boyacá Chicó | - | Audax Italiano | 4:3 (2:2) | ||
| 2nd (2nd leg) | Audax Italiano | - | Boyacá Chicó | 1:0 (0:0) | ||
| 1st(1st leg): 07/02/2008 | 2nd (2nd leg): 12/02/2008 | Winner: Audax Italiano | ||||
