 |
 |
|
|
| 1st(1st leg) | Sol de América | - | Atlético Nacional | 1:1 (0:1) | ||
| 2nd (2nd leg) | Atlético Nacional | - | Sol de América | 2:0 (0:0) | ||
| 1st(1st leg): 21/09/2016 00:45 | 2nd (2nd leg): 28/09/2016 01:45 | Winner: Atlético Nacional | ||||
| 1st(1st leg) | Independiente | - | Chapecoense | 0:0 (0:0) | ||
| 2nd (2nd leg) | Chapecoense | - | Independiente | 5:4 (0:0, 0:0) pso | ||
| 1st(1st leg): 21/09/2016 23:15 | 2nd (2nd leg): 28/09/2016 23:15 | Winner: Chapecoense | ||||
| 1st(1st leg) | Montevideo Wanderers | - | Atlético Junior | 0:0 (0:0) | ||
| 2nd (2nd leg) | Atlético Junior | - | Montevideo Wanderers | 4:3 (0:0, 0:0) pso | ||
| 1st(1st leg): 21/09/2016 23:15 | 2nd (2nd leg): 28/09/2016 23:15 | Winner: Atlético Junior | ||||
| 1st(1st leg) | Independiente Medellín | - | Santa Cruz - PE | 2:0 (1:0) | ||
| 2nd (2nd leg) | Santa Cruz - PE | - | Independiente Medellín | 3:1 (2:0) | ||
| 1st(1st leg): 22/09/2016 01:45 | 2nd (2nd leg): 29/09/2016 01:45 | Winner: Independiente Medellín | ||||
| 1st(1st leg) | Coritiba - PR | - | Belgrano de Córdoba | 1:2 (0:1) | ||
| 2nd (2nd leg) | Belgrano de Córdoba | - | Coritiba - PR | 3:4 (1:1, 1:2) pso | ||
| 1st(1st leg): 22/09/2016 01:45 | 2nd (2nd leg): 29/09/2016 01:45 | Winner: Coritiba - PR | ||||
| 1st(1st leg) | Palestino | - | Flamengo RJ | 0:1 (0:0) | ||
| 2nd (2nd leg) | Flamengo RJ | - | Palestino | 1:2 (0:2) | ||
| 1st(1st leg): 22/09/2016 01:45 | 2nd (2nd leg): 29/09/2016 01:45 | Winner: Palestino | ||||
| 1st(1st leg) | San Lorenzo | - | Deportivo La Guaira | 2:1 (2:0) | ||
| 2nd (2nd leg) | Deportivo La Guaira | - | San Lorenzo | 0:2 (0:2) | ||
| 1st(1st leg): 22/09/2016 23:15 | 2nd (2nd leg): 29/09/2016 23:15 | Winner: San Lorenzo | ||||
| 1st(1st leg) | Santa Fe | - | Cerro Porteño | 2:0 (1:0) | ||
| 2nd (2nd leg) | Cerro Porteño | - | Santa Fe | 4:1 (3:0) | ||
| 1st(1st leg): 23/09/2016 01:45 | 2nd (2nd leg): 30/09/2016 01:45 | Winner: Cerro Porteño | ||||
