FA Cup   M. W D L goals
  at home 1 0 1 0 2 : 2
  Away 1 0 0 1 0 : 2
  2 0 1 1 2 : 4
League Two   M. W D L goals
  at home 1 1 0 0 3 : 0
  Away 1 1 0 0 1 : 0
  2 2 0 0 4 : 0
National League   M. W D L goals
  at home 2 2 0 0 2 : 0
  Away 2 0 2 0 2 : 2
  4 2 2 0 4 : 2
overall   M. W D L goals
  at home 4 3 1 0 7 : 2
  Away 4 1 2 1 3 : 4
  Neutral Place 0 0 0 0 0 : 0
  8 4 3 1 10 : 6
FA Cup
1949/1950 2. Round Southend United - Wrexham AFC 2:0
1949/1950 2. Round Wrexham AFC - Southend United 2:2
League Two
2002/2003 32. Round Wrexham AFC - Southend United 3:0
2002/2003 17. Round Southend United - Wrexham AFC 0:1
National League
2022/2023 38. Round Wrexham AFC - Southend United 1:0 (1:0)
2022/2023 10. Round Southend United - Wrexham AFC 0:0 (0:0)
2021/2022 43. Round Wrexham AFC - Southend United 1:0 (0:0)
2021/2022 4. Round Southend United - Wrexham AFC 2:2 (1:0)

For games that were decided on penalties the score after 120 minutes will be included in the ranking