| 1. Round | 14/08/2022 | SC Paderborn 07 [Youth B] | - | Arminia Bielefeld [Youth B] | 2:3 |  |
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| 3. Round | 28/08/2022 | SC Paderborn 07 [Youth B] | - | Bor. Mönchengladbach [Youth B] | 2:2 |  |
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| 4. Round | 03/09/2022 | Preußen Münster [Youth B] | - | SC Paderborn 07 [Youth B] | 2:2 | |
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| 5. Round | 11/09/2022 | 1. FC Köln [Youth B] | - | SC Paderborn 07 [Youth B] | 5:1 | ||||
| 6. Round | 18/09/2022 | SC Paderborn 07 [Youth B] | - | Rot-Weiss Essen [Youth B] | 2:2 | ||||
| 7. Round | 01/10/2022 | FC Hennef 05 [Youth B] | - | SC Paderborn 07 [Youth B] | 0:2 | ||||
| 8. Round | 09/10/2022 | SC Paderborn 07 [Youth B] | - | Bayer Leverkusen [Youth B] | 0:4 | ||||
| 9. Round | 30/10/2022 | SV Deutz 05 [Youth B] | - | SC Paderborn 07 [Youth B] | 1:2 | |
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| 10. Round | 05/11/2022 | SC Paderborn 07 [Youth B] | - | VfL Bochum [Youth B] | 1:1 |  |
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| 12. Round | 19/11/2022 | SC Paderborn 07 [Youth B] | - | Borussia Dortmund [Youth B] | 1:5 |
Germany