1. Round | 29/08/2021 | FCE Rheine | - | SC Paderborn 07 II | 1:0 | ||||
2. Round | 05/09/2021 | SC Paderborn 07 II | - | TSG Sprockhövel | 4:0 | ||||
3. Round | 12/09/2021 | Hammer SpVg | - | SC Paderborn 07 II | 1:3 | ||||
4. Round | 19/09/2021 | SC Paderborn 07 II | - | Sportfreunde Siegen | 3:1 | ||||
5. Round | 26/09/2021 | SpVgg Vreden | - | SC Paderborn 07 II | 0:5 | ||||
6. Round | 03/10/2021 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
7. Round | 10/10/2021 | TuS Haltern | - | SC Paderborn 07 II | 2:5 | ||||
8. Round | 17/10/2021 | SC Paderborn 07 II | - | TuS Erndtebrück | 5:0 | ||||
9. Round | 23/10/2021 | Preußen Münster II | - | SC Paderborn 07 II | 0:4 | ||||
12. Round | 14/11/2021 | Westfalia Herne | - | SC Paderborn 07 II | 1:2 | ||||
13. Round | 20/11/2021 | SC Paderborn 07 II | - | Westfalia Rhynern | 0:3 | ||||
15. Round | 05/12/2021 | SC Paderborn 07 II | - | ASC 09 Dortmund | 3:1 | ||||
11. Round | 08/12/2021 | SC Paderborn 07 II | - | RSV Meinerzhagen | 5:1 | ||||
16. Round | 12/12/2021 | SG Finnentrop/Bamenohl | - | SC Paderborn 07 II | 2:2 | ||||
17. Round | 20/02/2022 | SC Paderborn 07 II | - | 1. FC Kaan-Marienborn | 1:1 |