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| 1st(1st leg) | Sportivo Luqueño | - | Deportivo Cuenca | 2:0 (2:0) | ||
| 2nd (2nd leg) | Deportivo Cuenca | - | Sportivo Luqueño | 6:5 (0:0, 2:0) pso | ||
| 1st(1st leg): 13/02/2018 22:15 | 2nd (2nd leg): 08/03/2018 00:45 | Winner: Deportivo Cuenca | ||||
| 1st(1st leg) | Universidad Técnica | - | Rampla Juniors | 2:0 (1:0) | ||
| 2nd (2nd leg) | Rampla Juniors | - | Universidad Técnica | 4:0 (2:0) | ||
| 1st(1st leg): 13/02/2018 22:15 | 2nd (2nd leg): 08/03/2018 22:15 | Winner: Rampla Juniors | ||||
| 1st(1st leg) | Zamora FC | - | Colón de Santa Fe | 0:2 (0:1) | ||
| 2nd (2nd leg) | Colón de Santa Fe | - | Zamora FC | 1:0 (0:0) | ||
| 1st(1st leg): 14/02/2018 00:30 | 2nd (2nd leg): 07/03/2018 00:45 | Winner: Colón de Santa Fe | ||||
| 1st(1st leg) | Club Nacional | - | Mineros de Guayana | 0:0 (0:0) | ||
| 2nd (2nd leg) | Mineros de Guayana | - | Club Nacional | 3:4 (0:0, 0:0) pso | ||
| 1st(1st leg): 15/02/2018 22:15 | 2nd (2nd leg): 08/03/2018 22:15 | Winner: Club Nacional | ||||
| 1st(1st leg) | Defensa y Justicia | - | América de Cali | 0:1 (0:1) | ||
| 2nd (2nd leg) | América de Cali | - | Defensa y Justicia | 0:3 (0:1) | ||
| 1st(1st leg): 16/02/2018 00:30 | 2nd (2nd leg): 09/03/2018 00:45 | Winner: Defensa y Justicia | ||||
| 1st(1st leg) | Unión Española | - | Sport Huancayo | 0:0 (0:0) | ||
| 2nd (2nd leg) | Sport Huancayo | - | Unión Española | 3:0 (1:0) | ||
| 1st(1st leg): 16/02/2018 00:30 | 2nd (2nd leg): 09/03/2018 00:45 | Winner: Sport Huancayo | ||||
| 1st(1st leg) | Sport Rosario | - | CA Cerro | 0:0 (0:0) | ||
| 2nd (2nd leg) | CA Cerro | - | Sport Rosario | 2:0 (0:0) | ||
| 1st(1st leg): 20/02/2018 22:15 | 2nd (2nd leg): 07/03/2018 22:15 | Winner: CA Cerro | ||||
| 1st(1st leg) | Barcelona | - | General Díaz | 0:0 (0:0) | ||
| 2nd (2nd leg) | General Díaz | - | Barcelona | 2:1 (0:0) | ||
| 1st(1st leg): 21/02/2018 00:30 | 2nd (2nd leg): 07/03/2018 22:15 | Winner: General Díaz | ||||
| 1st(1st leg) | Lanús | - | Sporting Cristal | 4:2 (3:1) | ||
| 2nd (2nd leg) | Sporting Cristal | - | Lanús | 2:1 (1:0) | ||
| 1st(1st leg): 21/02/2018 22:15 | 2nd (2nd leg): 08/03/2018 00:45 | Winner: Lanús | ||||
| 1st(1st leg) | El Nacional | - | San José | 3:2 (2:1) | ||
| 2nd (2nd leg) | San José | - | El Nacional | 1:1 (0:0) | ||
| 1st(1st leg): 22/02/2018 22:15 | 2nd (2nd leg): 06/03/2018 22:15 | Winner: El Nacional | ||||
| 1st(1st leg) | Everton | - | Caracas FC | 1:2 (0:0) | ||
| 2nd (2nd leg) | Caracas FC | - | Everton | 0:1 (0:0) | ||
| 1st(1st leg): 23/02/2018 00:30 | 2nd (2nd leg): 07/03/2018 00:45 | Winner: Caracas FC | ||||
| 1st(1st leg) | LDU Quito | - | CD Guabirá | 2:1 (2:0) | ||
| 2nd (2nd leg) | CD Guabirá | - | LDU Quito | 3:2 (1:0) | ||
| 1st(1st leg): 10/04/2018 23:15 | 2nd (2nd leg): 08/05/2018 23:15 | Winner: LDU Quito | ||||
| 1st(1st leg) | Jaguares de Córdoba | - | Boston River | 2:1 (0:0) | ||
| 2nd (2nd leg) | Boston River | - | Jaguares de Córdoba | 3:0 (1:0) | ||
| 1st(1st leg): 10/04/2018 23:15 | 2nd (2nd leg): 10/05/2018 23:15 | Winner: Boston River | ||||
| 1st(1st leg) | Deportivo Cali | - | Danubio | 3:0 (1:0) | ||
| 2nd (2nd leg) | Danubio | - | Deportivo Cali | 3:2 (1:0) | ||
| 1st(1st leg): 11/04/2018 01:30 | 2nd (2nd leg): 09/05/2018 01:45 | Winner: Deportivo Cali | ||||
| 1st(1st leg) | San Lorenzo | - | Atlético Mineiro | 1:0 (1:0) | ||
| 2nd (2nd leg) | Atlético Mineiro | - | San Lorenzo | 0:0 (0:0) | ||
| 1st(1st leg): 11/04/2018 23:15 | 2nd (2nd leg): 09/05/2018 01:45 | Winner: San Lorenzo | ||||
| 1st(1st leg) | Blooming | - | Bahia - BA | 1:0 (0:0) | ||
| 2nd (2nd leg) | Bahia - BA | - | Blooming | 4:0 (1:0) | ||
| 1st(1st leg): 12/04/2018 01:45 | 2nd (2nd leg): 24/05/2018 01:45 | Winner: Bahia - BA | ||||
| 1st(1st leg) | Fluminense RJ | - | Nacional Potosí | 3:0 (0:0) | ||
| 2nd (2nd leg) | Nacional Potosí | - | Fluminense RJ | 2:0 (0:0) | ||
| 1st(1st leg): 12/04/2018 01:45 | 2nd (2nd leg): 11/05/2018 01:45 | Winner: Fluminense RJ | ||||
| 1st(1st leg) | Athletico Paranaense | - | Newell's Old Boys | 3:0 (3:0) | ||
| 2nd (2nd leg) | Newell's Old Boys | - | Athletico Paranaense | 2:1 (1:0) | ||
| 1st(1st leg): 12/04/2018 23:15 | 2nd (2nd leg): 10/05/2018 23:15 | Winner: Athletico Paranaense | ||||
| 1st(1st leg) | Audax Italiano | - | Botafogo - RJ | 1:2 (1:0) | ||
| 2nd (2nd leg) | Botafogo - RJ | - | Audax Italiano | 1:1 (0:0) | ||
| 1st(1st leg): 12/04/2018 23:15 | 2nd (2nd leg): 10/05/2018 01:45 | Winner: Botafogo - RJ | ||||
| 1st(1st leg) | Sol de América | - | Independiente Medellín | 2:0 (1:0) | ||
| 2nd (2nd leg) | Independiente Medellín | - | Sol de América | 3:1 (1:1) | ||
| 1st(1st leg): 13/04/2018 01:30 | 2nd (2nd leg): 11/05/2018 01:45 | Winner: Sol de América | ||||
| 1st(1st leg) | Rosario Central | - | São Paulo FC | 0:0 (0:0) | ||
| 2nd (2nd leg) | São Paulo FC | - | Rosario Central | 1:0 (0:0) | ||
| 1st(1st leg): 13/04/2018 01:30 | 2nd (2nd leg): 10/05/2018 01:45 | Winner: São Paulo FC | ||||
| 1st(1st leg) | Estudiantes de Mérida | - | Deportes Temuco | 1:1 (0:0) | ||
| 2nd (2nd leg) | Deportes Temuco | - | Estudiantes de Mérida | 2:0 (1:0) | ||
| 1st(1st leg): 18/04/2018 23:15 | 2nd (2nd leg): 09/05/2018 23:15 | Winner: Deportes Temuco | ||||
