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| 09/04/2022 | 11:00 | Preußen Münster | - | SC Paderborn 07 | 1:5 (0:2) | |
| 12:00 | Fortuna Köln | - | FC Hennef 05 | 0:2 (0:1) | ||
| 12:00 | Alemannia Aachen | - | FC Schalke 04 | 0:4 (0:2) | ||
| 12:00 | VfL Bochum | - | Rot-Weiss Essen | 2:3 (0:1) | ||
| 12:00 | 1. FC Köln | - | SV Lippstadt 08 | 5:1 (3:0) | ||
| 12:00 | Bayer Leverkusen | - | Wuppertaler SV | 4:1 (1:0) | ||
| 12:00 | Arminia Bielefeld | - | SG Unterrath 12/24 | 3:0 (0:0) | ||
| 12:00 | Fortuna Düsseldorf | - | Bor. Mönchengladbach | 0:0 (0:0) |
| » Tables | Home | Away | First round | Second round | First half | Second half |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Schalke 04 | 15 | 13 | 1 | 1 | 45:6 | 39 | 40 |
| 2 |
|
Fortuna Düsseldorf | 15 | 12 | 2 | 1 | 44:14 | 30 | 38 |
| 3 |
|
Bor. Mönchengladbach | 15 | 11 | 2 | 2 | 39:9 | 30 | 35 |
| 4 |
|
Borussia Dortmund | 15 | 9 | 4 | 2 | 38:14 | 24 | 31 |
| 5 |
|
VfL Bochum | 15 | 9 | 0 | 6 | 43:22 | 21 | 27 |
| 6 |
|
Preußen Münster | 15 | 9 | 0 | 6 | 31:26 | 5 | 27 |
| 7 |
|
SC Paderborn 07 | 15 | 7 | 3 | 5 | 31:26 | 5 | 24 |
| 8 |
|
1. FC Köln | 15 | 7 | 2 | 6 | 26:18 | 8 | 23 |
| 9 |
|
Fortuna Köln | 15 | 7 | 1 | 7 | 17:25 | -8 | 22 |
| 10 |
|
Rot-Weiss Essen | 15 | 7 | 0 | 8 | 18:31 | -13 | 21 |
| 11 |
|
Arminia Bielefeld | 15 | 5 | 5 | 5 | 25:25 | 0 | 20 |
| 12 |
|
FC Hennef 05 | 16 | 6 | 0 | 10 | 16:26 | -10 | 18 |
| 13 |
|
Bayer Leverkusen | 15 | 5 | 2 | 8 | 15:24 | -9 | 17 |
| 14 |
|
Alemannia Aachen | 15 | 3 | 2 | 10 | 16:37 | -21 | 11 |
| 15 |
|
SG Unterrath 12/24 | 15 | 1 | 4 | 10 | 11:34 | -23 | 7 |
| 16 |
|
SV Lippstadt 08 | 15 | 2 | 0 | 13 | 11:46 | -35 | 6 |
| 17 |
|
Wuppertaler SV | 15 | 0 | 2 | 13 | 7:50 | -43 | 2 |
| Playoffs | |
| Relegation |
