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| 18/04/2022 | 14:00 | ASC 09 Dortmund | - | FCE Rheine | 4:4 (0:2) | |
| 14:00 | SC Paderborn 07 II | - | SV Schermbeck | 1:0 (1:0) | ||
| 14:00 | SG Wattenscheid 09 | - | 1. FC Kaan-Marienborn | 1:1 (0:0) | ||
| 14:00 | Westfalia Rhynern | - | FC Gütersloh | 1:0 (0:0) | ||
| 14:00 | Sportfreunde Siegen | - | TuS Erndtebrück | 1:0 (0:0) |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Paderborn 07 II | 22 | 15 | 4 | 3 | 59:20 | 39 | 49 |
| 2 |
|
1. FC Kaan-Marienborn | 22 | 14 | 6 | 2 | 53:21 | 32 | 48 |
| 3 |
|
SG Wattenscheid 09 | 22 | 14 | 4 | 4 | 41:23 | 18 | 46 |
| 4 |
|
Westfalia Rhynern | 22 | 14 | 1 | 7 | 54:25 | 29 | 43 |
| 5 |
|
FC Gütersloh | 22 | 11 | 7 | 4 | 30:14 | 16 | 40 |
| 6 |
|
ASC 09 Dortmund | 22 | 11 | 5 | 6 | 52:40 | 12 | 38 |
| 7 |
|
FCE Rheine | 22 | 12 | 2 | 8 | 40:37 | 3 | 38 |
| 8 |
|
Sportfreunde Siegen | 22 | 9 | 8 | 5 | 38:35 | 3 | 35 |
| 9 |
|
TuS Erndtebrück | 22 | 10 | 4 | 8 | 36:40 | -4 | 34 |
| 10 |
|
SV Schermbeck | 22 | 10 | 2 | 10 | 36:30 | 6 | 32 |
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