1. Round | 15/08/2021 | FC Schalke 04 II | - | 1. FC Köln II | 1:2 | ||||
2. Round | 21/08/2021 | Alemannia Aachen | - | FC Schalke 04 II | 1:1 | ||||
5. Round | 04/09/2021 | FC Schalke 04 II | - | FC Wegberg-Beeck | 2:0 | ||||
6. Round | 10/09/2021 | SV Rödinghausen | - | FC Schalke 04 II | 1:0 | ||||
9. Round | 25/09/2021 | FC Schalke 04 II | - | SV 19 Straelen | 1:1 | ||||
10. Round | 02/10/2021 | Wuppertaler SV | - | FC Schalke 04 II | 3:0 | ||||
13. Round | 23/10/2021 | FC Schalke 04 II | - | VfB Homberg | 0:0 | ||||
14. Round | 29/10/2021 | Preußen Münster | - | FC Schalke 04 II | 3:0 | ||||
17. Round | 20/11/2021 | Rot-Weiß Oberhausen | - | FC Schalke 04 II | 4:0 | ||||
18. Round | 26/11/2021 | FC Schalke 04 II | - | KFC Uerdingen 05 | 4:1 | ||||
19. Round | 04/12/2021 | SC Wiedenbrück | - | FC Schalke 04 II | 2:2 | ||||
21. Round | 18/12/2021 | FC Schalke 04 II | - | Alemannia Aachen | 1:1 | ||||
22. Round | 22/01/2022 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 1:4 | ||||
31. Round | 25/03/2022 | FC Schalke 04 II | - | Fortuna Düsseldorf II | 0:4 |