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| 1st(1st leg) | Spartak Moskva | - | Real Madrid | 0:0 (0:0) | ||
| 2nd (2nd leg) | Real Madrid | - | Spartak Moskva | 2:0 (0:0) | ||
| 1st(1st leg): 04/03/1981 15:00 | 2nd (2nd leg): 19/03/1981 17:00 | Winner: Real Madrid | ||||
| 1st(1st leg) | Liverpool FC | - | CSKA Sofia | 5:1 (2:0) | ||
| 2nd (2nd leg) | CSKA Sofia | - | Liverpool FC | 0:1 (0:1) | ||
| 1st(1st leg): 04/03/1981 18:30 | 2nd (2nd leg): 18/03/1981 17:00 | Winner: Liverpool FC | ||||
| 1st(1st leg) | Bayern München | - | TJ Baník Ostrava OKD | 2:0 (0:0) | ||
| 2nd (2nd leg) | TJ Baník Ostrava OKD | - | Bayern München | 2:4 (1:4) | ||
| 1st(1st leg): 04/03/1981 19:00 | 2nd (2nd leg): 18/03/1981 15:30 | Winner: Bayern München | ||||
| 1st(1st leg) | Inter | - | Crvena Zvezda | 1:1 (1:0) | ||
| 2nd (2nd leg) | Crvena Zvezda | - | Inter | 0:1 (0:1) | ||
| 1st(1st leg): 04/03/1981 19:45 | 2nd (2nd leg): 18/03/1981 16:30 | Winner: Inter | ||||
