1st(1st leg) Spora Luxemburg - TJ Sparta ČKD Praha 0:6 (0:2)
2nd (2nd leg) TJ Sparta ČKD Praha - Spora Luxemburg 6:0 (2:0)
1st(1st leg): 16/09/1980 2nd (2nd leg): 01/10/1980 Winner: TJ Sparta ČKD Praha
1st(1st leg) Slavia Sofia - Legia Warszawa 3:1 (0:1)
2nd (2nd leg) Legia Warszawa - Slavia Sofia 1:0 (0:0)
1st(1st leg): 16/09/1980 2nd (2nd leg): 01/10/1980 Winner: Slavia Sofia
1st(1st leg) Newport County - Crusaders FC 4:0 (2:0)
2nd (2nd leg) Crusaders FC - Newport County 0:0 (0:0)
1st(1st leg): 16/09/1980 2nd (2nd leg): 01/10/1980 Winner: Newport County
1st(1st leg) Hvidovre IF - Fram Reykjavík 1:0 (1:0)
2nd (2nd leg) Fram Reykjavík - Hvidovre IF 0:2 (0:1)
1st(1st leg): 17/09/1980 2nd (2nd leg): 28/09/1980 Winner: Hvidovre IF
1st(1st leg) Dinamo Zagreb - SL Benfica 0:0 (0:0)
2nd (2nd leg) SL Benfica - Dinamo Zagreb 2:0 (1:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: SL Benfica
1st(1st leg) Ilves Tampere - Feyenoord 1:3 (1:1)
2nd (2nd leg) Feyenoord - Ilves Tampere 4:2 (1:1)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: Feyenoord
1st(1st leg) Malmö FF - FK Partizani 1:0 (0:0)
2nd (2nd leg) FK Partizani - Malmö FF 0:0 (0:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: Malmö FF
1st(1st leg) Fortuna Düsseldorf - SV Austria Salzburg 5:0 (2:0)
2nd (2nd leg) SV Austria Salzburg - Fortuna Düsseldorf 0:3 (0:1)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: Fortuna Düsseldorf
1st(1st leg) Valencia CF - AS Monaco 2:0 (0:0)
2nd (2nd leg) AS Monaco - Valencia CF 3:3 (2:1)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: Valencia CF
1st(1st leg) Castilla CF - West Ham United 3:1 (0:1)
2nd (2nd leg) West Ham United - Castilla CF 5:1 (3:0, 3:1) aet
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: West Ham United
1st(1st leg) AS Roma - FC Carl Zeiss Jena 3:0 (2:0)
2nd (2nd leg) FC Carl Zeiss Jena - AS Roma 4:0 (2:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: FC Carl Zeiss Jena
1st(1st leg) FC Sion - SK Haugar 1:1 (0:1)
2nd (2nd leg) SK Haugar - FC Sion 2:0 (1:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: SK Haugar
1st(1st leg) AGS Kastoria - Dinamo Tbilisi 0:0 (0:0)
2nd (2nd leg) Dinamo Tbilisi - AGS Kastoria 2:0 (0:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: Dinamo Tbilisi
1st(1st leg) Omonia Nikosia - K Waterschei SV Thor Genk 1:3 (0:1)
2nd (2nd leg) K Waterschei SV Thor Genk - Omonia Nikosia 4:0 (1:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: K Waterschei SV Thor Genk
1st(1st leg) Celtic FC - CS Politechnica Timisoara 2:1 (2:0)
2nd (2nd leg) CS Politechnica Timisoara - Celtic FC 1:0 (0:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: CS Politechnica Timisoara
1st(1st leg) Hibernians FC - Waterford AFC 1:0 (0:0)
2nd (2nd leg) Waterford AFC - Hibernians FC 4:0 (3:0)
1st(1st leg): 17/09/1980 2nd (2nd leg): 01/10/1980 Winner: Waterford AFC