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| 1st(1st leg) | Sporting Braga | - | Shakhtar Donetsk | 1:2 (0:1) | ||
| 2nd (2nd leg) | Shakhtar Donetsk | - | Sporting Braga | 4:0 (2:0) | ||
| 1st(1st leg): 07/04/2016 20:05 | 2nd (2nd leg): 14/04/2016 20:05 | Winner: Shakhtar Donetsk | ||||
| 1st(1st leg) | Villarreal CF | - | AC Sparta Praha | 2:1 (1:1) | ||
| 2nd (2nd leg) | AC Sparta Praha | - | Villarreal CF | 2:4 (0:3) | ||
| 1st(1st leg): 07/04/2016 20:05 | 2nd (2nd leg): 14/04/2016 20:05 | Winner: Villarreal CF | ||||
| 1st(1st leg) | Athletic Bilbao | - | Sevilla FC | 1:2 (0:0) | ||
| 2nd (2nd leg) | Sevilla FC | - | Athletic Bilbao | 5:4 (0:0, 1:2, 1:2) pso | ||
| 1st(1st leg): 07/04/2016 20:05 | 2nd (2nd leg): 14/04/2016 20:05 | Winner: Sevilla FC | ||||
| 1st(1st leg) | Borussia Dortmund | - | Liverpool FC | 1:1 (0:1) | ||
| 2nd (2nd leg) | Liverpool FC | - | Borussia Dortmund | 4:3 (0:2) | ||
| 1st(1st leg): 07/04/2016 20:05 | 2nd (2nd leg): 14/04/2016 20:05 | Winner: Liverpool FC | ||||
