1st(1st leg) Apollon Limassol - WFC Zhytlobud-1 Kharkiv 1:2 (1:1)
2nd (2nd leg) WFC Zhytlobud-1 Kharkiv - Apollon Limassol 3:1 (2:0)
1st(1st leg): 31/08/2021 16:00 2nd (2nd leg): 09/09/2021 16:00 Winner: WFC Zhytlobud-1 Kharkiv
1st(1st leg) FC Rosengård - 1899 Hoffenheim 0:3 (0:1)
2nd (2nd leg) 1899 Hoffenheim - FC Rosengård 3:3 (2:1)
1st(1st leg): 31/08/2021 18:00 2nd (2nd leg): 08/09/2021 18:00 Winner: 1899 Hoffenheim
1st(1st leg) FC Twente - SL Benfica 1:1 (1:1)
2nd (2nd leg) SL Benfica - FC Twente 4:0 (1:0)
1st(1st leg): 31/08/2021 18:30 2nd (2nd leg): 09/09/2021 19:00 Winner: SL Benfica
1st(1st leg) Arsenal WFC - Slavia Praha 3:0 (2:0)
2nd (2nd leg) Slavia Praha - Arsenal WFC 0:4 (0:0)
1st(1st leg): 31/08/2021 19:30 2nd (2nd leg): 09/09/2021 17:30 Winner: Arsenal WFC
1st(1st leg) Real Madrid - Manchester City WFC 1:1 (0:0)
2nd (2nd leg) Manchester City WFC - Real Madrid 0:1 (0:1)
1st(1st leg): 31/08/2021 20:00 2nd (2nd leg): 08/09/2021 19:00 Winner: Real Madrid
1st(1st leg) AC Sparta Praha - HB Køge 0:1 (0:0)
2nd (2nd leg) HB Køge - AC Sparta Praha 2:0 (0:0)
1st(1st leg): 01/09/2021 17:00 2nd (2nd leg): 08/09/2021 17:00 Winner: HB Køge
1st(1st leg) VfL Wolfsburg - Girondins Bordeaux 3:2 (2:1)
2nd (2nd leg) Girondins Bordeaux - VfL Wolfsburg 0:3 (1:1, 2:1, 3:2) pso
1st(1st leg): 01/09/2021 17:00 2nd (2nd leg): 08/09/2021 18:00 Winner: VfL Wolfsburg
1st(1st leg) ŽNK Osijek - Breiðablik 1:1 (1:1)
2nd (2nd leg) Breiðablik - ŽNK Osijek 3:0 (2:0)
1st(1st leg): 01/09/2021 17:00 2nd (2nd leg): 09/09/2021 18:00 Winner: Breiðablik
1st(1st leg) FK Vllaznia - Juventus 0:2 (0:2)
2nd (2nd leg) Juventus - FK Vllaznia 1:0 (1:0)
1st(1st leg): 01/09/2021 18:00 2nd (2nd leg): 09/09/2021 19:00 Winner: Juventus
1st(1st leg) Vålerenga IF - BK Häcken 1:3 (0:2)
2nd (2nd leg) BK Häcken - Vålerenga IF 3:2 (1:0)
1st(1st leg): 01/09/2021 18:00 2nd (2nd leg): 08/09/2021 18:00 Winner: BK Häcken
1st(1st leg) Servette FCCF - Glasgow City FC 1:1 (0:0)
2nd (2nd leg) Glasgow City FC - Servette FCCF 1:2 (1:1)
1st(1st leg): 01/09/2021 18:15 2nd (2nd leg): 08/09/2021 15:10 Winner: Servette FCCF
1st(1st leg) Levante UD - Olympique Lyonnais 1:2 (0:0)
2nd (2nd leg) Olympique Lyonnais - Levante UD 2:1 (0:0)
1st(1st leg): 01/09/2021 20:00 2nd (2nd leg): 08/09/2021 17:00 Winner: Olympique Lyonnais