| 4. Round | 20/11/2021 | USM Alger | - | US Biskra | 3:0 | ||||
| 11. Round | 03/01/2022 | US Biskra | - | WA Tlemcen | 0:0 | ||||
| 13. Round | 16/01/2022 | US Biskra | - | CS Constantine | 2:0 | ||||
| 14. Round | 21/01/2022 | Paradou AC | - | US Biskra | 1:0 | ||||
| 15. Round | 25/01/2022 | US Biskra | - | Olympique Médéa | 2:1 | ||||
| 16. Round | 29/01/2022 | ES Sétif | - | US Biskra | 2:0 | ||||
| 17. Round | 05/02/2022 | US Biskra | - | NA Hussein Dey | 2:1 | ||||
| 18. Round | 25/02/2022 | US Biskra | - | RC Arbaâ | 1:0 | ||||
| 20. Round | 05/03/2022 | RC Rélizane | - | US Biskra | 1:1 | ||||
| 19. Round | 24/03/2022 | JS Saoura | - | US Biskra | 2:0 | ||||
| 23. Round | 28/03/2022 | US Biskra | - | JS Kabylie | 0:1 | ||||
| 24. Round | 01/04/2022 | ASO Chlef | - | US Biskra | 2:0 | ||||
| 28. Round | 29/04/2022 | WA Tlemcen | - | US Biskra | 0:3 | ||||
| 32. Round | 27/05/2022 | Olympique Médéa | - | US Biskra | 1:1 | ||||
| 26. Round | 31/05/2022 | CR Bélouizdad | - | US Biskra | 2:0 | ||||
| 33. Round | 05/06/2022 | US Biskra | - | ES Sétif | 1:1 | ||||
| 34. Round | 10/06/2022 | NA Hussein Dey | - | US Biskra | 1:2 |
Algeria