| 1. Round | 27/02/2022 | Zulia FC | - | Deportivo Lara | 0:1 | ||||
| 2. Round | 05/03/2022 | Deportivo Táchira | - | Zulia FC | 3:0 |  |
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| 3. Round | 11/03/2022 | Zulia FC | - | Metropolitanos FC | 1:2 | |
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| 4. Round | 19/03/2022 | Portuguesa FC | - | Zulia FC | 1:1 | |
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| 5. Round | 24/03/2022 | Zulia FC | - | Deportivo La Guaira | 0:2 | ||||
| 6. Round | 02/04/2022 | Aragua FC | - | Zulia FC | 0:0 | ||||
| 7. Round | 09/04/2022 | Monagas | - | Zulia FC | 2:0 | ||||
| 8. Round | 14/04/2022 | Zulia FC | - | Universidad Central | 2:2 | ||||
| 12. Round | 15/05/2022 | Zulia FC | - | Estudiantes de Mérida | 3:2 | ||||
| 14. Round | 26/05/2022 | Hermanos Colmenarez | - | Zulia FC | 0:2 | ||||
| 15. Round | 04/06/2022 | Zulia FC | - | Academia Puerto Cabello | 4:1 | ||||
| 16. Round | 11/06/2022 | Academia Puerto Cabello | - | Zulia FC | 2:2 | ||||
| 18. Round | 03/07/2022 | Caracas FC | - | Zulia FC | 3:1 | |
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| 20. Round | 17/07/2022 | Zulia FC | - | Carabobo FC | 2:0 | ||||
| 21. Round | 25/07/2022 | Zamora FC | - | Zulia FC | 5:1 |
Panama