| 1. Round | 07/08/2021 | Andrézieux-Bouthéon FC | - | Angers SCO B | 3:1 |  |
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| 2. Round | 14/08/2021 | Angers SCO B | - | US Colomiers | 0:0 | ||||
| 4. Round | 28/08/2021 | Angers SCO B | - | Canet Roussillon | 2:0 |  |
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| 6. Round | 11/09/2021 | Angers SCO B | - | Trélissac FC | 0:1 | |
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| 3. Round | 02/10/2021 | FC Nantes B | - | Angers SCO B | 1:1 | |
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| 9. Round | 09/10/2021 | Stade Montois | - | Angers SCO B | 0:4 | ||||
| 10. Round | 23/10/2021 | Angers SCO B | - | Bourges Foot 18 | 0:3 | |
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| 11. Round | 06/11/2021 | Le Puy Foot 43 | - | Angers SCO B | 1:0 | |
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| 14. Round | 11/12/2021 | Montpellier HSC B | - | Angers SCO B | 0:4 | ||||
| 15. Round | 15/01/2022 | Angers SCO B | - | FC Chamalières | 1:1 | ||||
| 16. Round | 22/01/2022 | US Colomiers | - | Angers SCO B | 0:0 | |
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| 18. Round | 12/02/2022 | Canet Roussillon | - | Angers SCO B | 2:0 | |
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| 21. Round | 12/03/2022 | Angers SCO B | - | Moulins Yzeure Foot | 1:1 | ||||
| 22. Round | 19/03/2022 | AS Béziers | - | Angers SCO B | 1:1 | ||||
| 23. Round | 26/03/2022 | Angers SCO B | - | Stade Montois | 0:0 | ||||
| 25. Round | 16/04/2022 | Angers SCO B | - | Le Puy Foot 43 | 0:2 |  |
France
Mali