| Qual. 2. Round | 16/10/2021 | Tusker FC | - | Zamalek | 0:1 |  |
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| Qual. 2. Round | 22/10/2021 | Zamalek | - | Tusker FC | 4:0 | |
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| Group D | 12/02/2022 | Zamalek | - | Petro Atlético | 2:2 | ||||
| Group D | 19/02/2022 | GD Sagrada Esperança | - | Zamalek | 0:0 | ||||
| Group D | 26/02/2022 | Wydad AC | - | Zamalek | 3:1 | ||||
| Group D | 11/03/2022 | Zamalek | - | Wydad AC | 0:1 | ||||
| Group D | 19/03/2022 | Petro Atlético | - | Zamalek | 0:0 | ||||
| Group D | 01/04/2022 | Zamalek | - | GD Sagrada Esperança | 0:0 |
Morocco