| 4. Round | 11/09/2021 | SV Zulte Waregem [U18] | - | Club Brugge KV [U18] | 1:1 | ||||
| 6. Round | 25/09/2021 | SV Zulte Waregem [U18] | - | RSC Anderlecht [U18] | 3:4 | ||||
| 8. Round | 09/10/2021 | SV Zulte Waregem [U18] | - | KV Mechelen [U18] | 3:1 | ||||
| 13. Round | 20/11/2021 | SV Zulte Waregem [U18] | - | Standard Liège [U18] | 0:0 | ||||
| 15. Round | 15/01/2022 | Cercle Brugge [U18] | - | SV Zulte Waregem [U18] | 1:1 | ||||
| 20. Round | 19/02/2022 | SV Zulte Waregem [U18] | - | Sporting Charleroi [U18] | 0:3 | ||||
| 22. Round | 12/03/2022 | KAA Gent [U18] | - | SV Zulte Waregem [U18] | 0:1 | ||||
| 24. Round | 26/03/2022 | Royal Antwerp FC [U18] | - | SV Zulte Waregem [U18] | 0:2 | ||||
| 25. Round | 02/04/2022 | KRC Genk [U18] | - | SV Zulte Waregem [U18] | 9:1 | ||||
| 26. Round | 23/04/2022 | Standard Liège [U18] | - | SV Zulte Waregem [U18] | 3:2 |
Belgium