| 21. Round | 07/02/2021 | AC Milan | - | FC Crotone | 4:0 | ||||
| 22. Round | 14/02/2021 | FC Crotone | - | Sassuolo Calcio | 1:2 |  |
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| 23. Round | 22/02/2021 | Juventus | - | FC Crotone | 3:0 | ||||
| 24. Round | 28/02/2021 | FC Crotone | - | Cagliari Calcio | 0:2 | ||||
| 26. Round | 07/03/2021 | FC Crotone | - | Torino FC | 4:2 | |
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| 27. Round | 12/03/2021 | Lazio Roma | - | FC Crotone | 3:2 | ||||
| 29. Round | 03/04/2021 | SSC Napoli | - | FC Crotone | 4:3 | ||||
| 30. Round | 10/04/2021 | Spezia Calcio | - | FC Crotone | 3:2 | ||||
| 31. Round | 17/04/2021 | FC Crotone | - | Udinese Calcio | 1:2 | ||||
| 33. Round | 24/04/2021 | Parma Calcio 1913 | - | FC Crotone | 3:4 | |
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| 34. Round | 01/05/2021 | FC Crotone | - | Inter | 0:2 | ||||
| 35. Round | 09/05/2021 | AS Roma | - | FC Crotone | 5:0 | ||||
| 36. Round | 13/05/2021 | FC Crotone | - | Hellas Verona | 2:1 | |
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| 37. Round | 16/05/2021 | Benevento Calcio | - | FC Crotone | 1:1 | ||||
| 38. Round | 22/05/2021 | FC Crotone | - | ACF Fiorentina | 0:0 |
France
