| 2. Round | 29/08/2021 | Genoa CFC | - | SSC Napoli | 1:2 | ||||
| 3. Round | 11/09/2021 | SSC Napoli | - | Juventus | 2:1 | ||||
| 4. Round | 20/09/2021 | Udinese Calcio | - | SSC Napoli | 0:4 | ||||
| 5. Round | 23/09/2021 | Sampdoria | - | SSC Napoli | 0:4 | ||||
| 6. Round | 26/09/2021 | SSC Napoli | - | Cagliari Calcio | 2:0 | ||||
| 12. Round | 07/11/2021 | SSC Napoli | - | Hellas Verona | 1:1 | ||||
| 16. Round | 04/12/2021 | SSC Napoli | - | Atalanta | 2:3 | ||||
| 17. Round | 12/12/2021 | SSC Napoli | - | Empoli FC | 0:1 | ||||
| 18. Round | 19/12/2021 | AC Milan | - | SSC Napoli | 0:1 | ||||
| 19. Round | 22/12/2021 | SSC Napoli | - | Spezia Calcio | 0:1 | ||||
| 25. Round | 12/02/2022 | SSC Napoli | - | Inter | 1:1 | ||||
| 26. Round | 21/02/2022 | Cagliari Calcio | - | SSC Napoli | 1:1 | ||||
| 27. Round | 27/02/2022 | Lazio Roma | - | SSC Napoli | 1:2 | ||||
| 28. Round | 06/03/2022 | SSC Napoli | - | AC Milan | 0:1 |  |
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| 34. Round | 24/04/2022 | Empoli FC | - | SSC Napoli | 3:2 |
France
