| 16. Round | 16/01/2022 | KS Kastrioti | - | KF Teuta Durrës | 2:0 | ||||
| 18. Round | 30/01/2022 | KS Kastrioti | - | FK Vllaznia | 0:1 | ||||
| 21. Round | 20/02/2022 | KS Kastrioti | - | KF Tiranë | 2:1 | ||||
| 22. Round | 26/02/2022 | Egnatia Rrogozhine | - | KS Kastrioti | 2:1 | ||||
| 23. Round | 03/03/2022 | KS Kastrioti | - | KF Skënderbeu | 1:0 | ||||
| 24. Round | 07/03/2022 | KS Kastrioti | - | KF Laçi | 1:1 |  |
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| 25. Round | 13/03/2022 | KF Teuta Durrës | - | KS Kastrioti | 0:1 | |
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| 26. Round | 19/03/2022 | KS Kastrioti | - | FK Partizani | 1:0 | ||||
| 27. Round | 04/04/2022 | FK Vllaznia | - | KS Kastrioti | 1:2 | |
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| 28. Round | 11/04/2022 | Dinamo Tiranë | - | KS Kastrioti | 0:1 |  |
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| 29. Round | 16/04/2022 | KS Kastrioti | - | FK Kukësi | 1:0 | ||||
| 30. Round | 24/04/2022 | KF Tiranë | - | KS Kastrioti | 0:1 | ||||
| 31. Round | 30/04/2022 | KS Kastrioti | - | Egnatia Rrogozhine | 2:1 | ||||
| 32. Round | 04/05/2022 | KF Skënderbeu | - | KS Kastrioti | 2:0 | ||||
| 33. Round | 08/05/2022 | KF Laçi | - | KS Kastrioti | 4:1 | ||||
| 34. Round | 14/05/2022 | KS Kastrioti | - | KF Teuta Durrës | 0:1 | ||||
| 36. Round | 26/05/2022 | KS Kastrioti | - | FK Vllaznia | 1:3 |
Albania