| 2. Round | 28/01/2021 | ART Municipal Jalapa | - | Junior Managua | 1:1 |  |
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| 3. Round | 31/01/2021 | ART Municipal Jalapa | - | CD Walter Ferretti | 2:0 | |
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| 4. Round | 04/02/2021 | Diriangén FC | - | ART Municipal Jalapa | 2:0 | ||||
| 5. Round | 08/02/2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 |  |
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| 6. Round | 10/02/2021 | Managua FC | - | ART Municipal Jalapa | 5:2 |  |
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| 10. Round | 08/03/2021 | ART Municipal Jalapa | - | Juventus Managua | 1:0 | |
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| 12. Round | 01/04/2021 | CD Walter Ferretti | - | ART Municipal Jalapa | 4:0 | |
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| 13. Round | 12/04/2021 | ART Municipal Jalapa | - | Diriangén FC | 0:2 | |
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| 14. Round | 20/04/2021 | Real Estelí FC | - | ART Municipal Jalapa | 1:0 | ||||
| 15. Round | 26/04/2021 | ART Municipal Jalapa | - | Managua FC | 2:2 | ||||
| 16. Round | 30/04/2021 | Club Deportivo Ocotal | - | ART Municipal Jalapa | 2:0 | |
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| 18. Round | 05/05/2021 | Real Madriz | - | ART Municipal Jalapa | 1:0 |
Nicaragua