| 1. Round | 29/07/2021 | AD San Carlos | - | LD Alajuelense | 2:2 |  |
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| 2. Round | 01/08/2021 | Guadalupe | - | AD San Carlos | 1:1 | |
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| 3. Round | 07/08/2021 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 4. Round | 11/08/2021 | CS Cartaginés | - | AD San Carlos | 5:1 | |
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| 5. Round | 14/08/2021 | AD San Carlos | - | Jicaral | 0:0 | ||||
| 6. Round | 18/08/2021 | CS Herediano | - | AD San Carlos | 2:0 | ||||
| 7. Round | 25/08/2021 | Sporting FC | - | AD San Carlos | 0:0 | ||||
| 8. Round | 30/08/2021 | AD San Carlos | - | AD Guanacasteca | 0:1 | ||||
| 9. Round | 08/09/2021 | Santos de Guápiles | - | AD San Carlos | 2:2 | ||||
| 10. Round | 13/09/2021 | AD San Carlos | - | Deportivo Saprissa | 1:0 | |
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| 11. Round | 15/09/2021 | Municipal Grecia | - | AD San Carlos | 3:2 | ||||
| 19. Round | 01/11/2021 | AD Guanacasteca | - | AD San Carlos | 0:1 | |
Panama