| 2. Round | 12/02/2022 | Sporting San Miguelito | - | Plaza Amador | 1:1 | ||||
| 4. Round | 27/02/2022 | Alianza | - | Sporting San Miguelito | 0:1 | ||||
| 5. Round | 05/03/2022 | Sporting San Miguelito | - | Potros del Este | 1:1 | ||||
| 6. Round | 08/03/2022 | UD Universitario | - | Sporting San Miguelito | 0:2 | ||||
| 7. Round | 13/03/2022 | Sporting San Miguelito | - | Herrera FC | 1:1 | ||||
| 9. Round | 26/03/2022 | San Francisco FC | - | Sporting San Miguelito | 0:1 | ||||
| 10. Round | 04/04/2022 | Sporting San Miguelito | - | Atlético Chiriquí | 4:1 | ||||
| 11. Round | 09/04/2022 | Sporting San Miguelito | - | Independiente de La Chorrera | 2:1 | ||||
| 13. Round | 23/04/2022 | Plaza Amador | - | Sporting San Miguelito | 1:1 | ||||
| 14. Round | 27/04/2022 | Sporting San Miguelito | - | Árabe Unido | 1:0 | ||||
| 15. Round | 30/04/2022 | Sporting San Miguelito | - | Alianza | 1:0 |
Panama