| 19. Round | 16/01/2022 | SC Cambuur | - | Sparta Rotterdam | 1:1 |  |
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| 20. Round | 23/01/2022 | Sparta Rotterdam | - | FC Utrecht | 0:3 |  |
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| 21. Round | 06/02/2022 | Feyenoord | - | Sparta Rotterdam | 4:0 | ||||
| 24. Round | 27/02/2022 | Sparta Rotterdam | - | PSV Eindhoven | 1:2 | ||||
| 26. Round | 12/03/2022 | Sparta Rotterdam | - | Go Ahead Eagles | 1:0 | ||||
| 27. Round | 19/03/2022 | NEC Nijmegen | - | Sparta Rotterdam | 0:0 | ||||
| 28. Round | 03/04/2022 | Sparta Rotterdam | - | sc Heerenveen | 1:1 | ||||
| 29. Round | 09/04/2022 | AFC Ajax | - | Sparta Rotterdam | 2:1 | ||||
| 23. Round | 16/04/2022 | Fortuna Sittard | - | Sparta Rotterdam | 3:0 | ||||
| 25. Round | 19/04/2022 | Vitesse | - | Sparta Rotterdam | 0:1 | |
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| 30. Round | 22/04/2022 | FC Twente | - | Sparta Rotterdam | 2:0 | ||||
| 31. Round | 30/04/2022 | Sparta Rotterdam | - | AZ Alkmaar | 1:1 |
Spain