| 5. Round | 21/08/2010 | Pandurii Târgu Jiu | - | Gaz Metan Mediaş | 0:0 | ||||
| 6. Round | 28/08/2010 | CFR Cluj | - | Pandurii Târgu Jiu | 2:1 | ||||
| 7. Round | 13/09/2010 | Pandurii Târgu Jiu | - | FC Universitatea Craiova | 3:1 | ||||
| 8. Round | 17/09/2010 | FC Victoria Brăneşti | - | Pandurii Târgu Jiu | 2:0 | ||||
| 9. Round | 26/09/2010 | Pandurii Târgu Jiu | - | FC Timişoara | 0:1 | ||||
| 10. Round | 01/10/2010 | Astra Ploieşti | - | Pandurii Târgu Jiu | 2:0 | ||||
| 11. Round | 16/10/2010 | Pandurii Târgu Jiu | - | Sportul Studenţesc | 1:0 | ||||
| 12. Round | 25/10/2010 | FC Steaua Bucureşti | - | Pandurii Târgu Jiu | 2:0 | ||||
| 16. Round | 19/11/2010 | Pandurii Târgu Jiu | - | FC Brașov | 2:1 | ||||
| 17. Round | 26/11/2010 | FC Vaslui | - | Pandurii Târgu Jiu | 3:1 |
Romania