| 1. Round | 06/02/2022 | Independiente Petrolero | - | Always Ready | 1:2 | ||||
| 2. Round | 12/02/2022 | Always Ready | - | Royal Pari | 2:2 | ||||
| 3. Round | 19/02/2022 | Always Ready | - | Real Tomayapo | 0:1 |  |
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| 4. Round | 27/02/2022 | Bolívar | - | Always Ready | 3:0 | |
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| 5. Round | 06/03/2022 | Always Ready | - | Jorge Wilstermann | 0:0 | ||||
| 7. Round | 02/04/2022 | Blooming | - | Always Ready | 1:0 | ||||
| 9. Round | 16/04/2022 | Always Ready | - | Independiente Petrolero | 1:1 | |
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| 10. Round | 20/04/2022 | Royal Pari | - | Always Ready | 5:1 | ||||
| 14. Round | 11/05/2022 | Jorge Wilstermann | - | Always Ready | 1:0 | |
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| 15. Round | 15/05/2022 | Always Ready | - | Blooming | 3:0 | ||||
| 16. Round | 22/05/2022 | Universitario de Vinto | - | Always Ready | 2:1 | |
Venezuela